Marginal ascorbate status (hypovitaminosis C) results in an attenuated response to vitamin C supplementation. However, in test tube experiments, vitamin C can interact with some free metal ions and lead to the generation of potentially damaging free radicals. Gao X, Curhan G, Forman JP, Ascherio A, Choi HK. Am Heart J. (PubMed), 40. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. 2001;98(17):9842-9846. (PubMed), 24. (PubMed), 140. Cabanillas F. Vitamin C and cancer: what can we conclude--1,609 patients and 33 years later? (PubMed), 139. 2014;6(9):3818-3846. Am J Epidemiol. J Urol. Years later, Dr. Linus Pauling, two-time Nobel Prize winner, is ignored for reporting that large amounts of vitamin C and lysine are needed to prevent coronary attacks. (PubMed), 34. A three-year randomized controlled trial in 160 patients with documented coronary heart disease and low blood HDL concentrations found that a combination of simvastatin (Zocor) and niacin increased HDL concentration, inhibited the progression of coronary artery stenosis (narrowing), and decreased the frequency of cardiovascular events, such as myocardial infarction and stroke(202). Cochrane Database Syst Rev. Int J Cancer. A 2015 meta-analysis of 29 randomized controlled trials found that administration of vitamin C during pregnancy, alone or in combination with a few other supplements, failed to reduce the risks of stillbirth, perinatal death, intrauterine growth restriction, preterm birth, premature rupture of membranes, and preeclampsia (88). Carr AC, Cook J. (PubMed), 163. University of Otago Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Lee DH, Lim JS, Song K, Boo Y, Jacobs DR, Jr. Graded associations of blood lead and urinary cadmium concentrations with oxidative-stress-related markers in the U.S. population: results from the third National Health and Nutrition Examination Survey. 2013;1(5):e239-240. Thompson CA, Cerhan JR. Fruit and vegetable intake and survival from non-Hodgkin lymphoma: does an apple a day keep the doctor away? Recall Matthias Rath and Linus Pauling's finding that lysine + vitamin C prevents Lipoprotein(a), a cholesterol-like particle, from forming within coronary arteries via its ability to take the place of Lp(a). Pal J, Sanal MG, Gopal GJ. There is no scientific evidence that large amounts of vitamin C (up to 10 grams [g]/day in adults) exert any adverse or toxic effects. Mineral salts of vitamin C are considered less acidic than vitamin C and therefore are considered "buffered." Int J Cancer. Chuang CH, Sheu BS, Kao AW, et al. (PubMed), 56. (PubMed), 19. 1996;173(6):1502-1505. New York: Plenum Press; 1996:215-231. A 2012 review of nine randomized controlled trials found no substantial effect of -carotene, vitamin C, and vitamin E, administered individually or in combination over 2.1 to 12 years, on the risk of cataracts or cataract surgery (112). Vitamin C and Cardiovascular Disease - orthomolecular.org Vitamin C. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. (PubMed), 206. Ascorbyl palmitate is marketed as "vitamin C ester," which should not be confused with Ester-C (see above). Oregon State University, Updated in September 2003 by: Another large, multi-center, prospective studythe Womens Health Initiativethat followed 154,363 postmenopausal women for 11 years found that dietary and supplemental vitamin C intake at baseline was inversely associated with diffuse B-cell lymphoma, a subtype of NHL (81). A meta-analysis of 29 small randomized controlled trials of short durations (median duration, 8 weeks) in 1,407 participants (10 to 120 subjects per trial; including both normotensive and hypertensive subjects) found that daily supplementation with 60 to 4,000 mg of vitamin C (median dose, 500 mg) reduced systolic blood pressure by 3.84 mm Hg and diastolic blood pressure by 1.48 mm Hg (45). PLoS One. Overall, an inverse association between fruit and vegetable intake and risk of NHL was observed. 22. Gut. 2015;6(4):570-581. The effect of vitamin C, alone or with allopurinol, decreasing serum uric acid was modest and much less than that of allopurinol alone. (PubMed), 18. Linus Pauling recommended at least 3000mg of vitamin C per day as a preventive dose, and significantly higher levels of both vitamin C and lysine for the treatment of existing heart disease. (PubMed), 174. On the other hand, two other large prospective studies reported that a high intake of vitamin C was associated with an increased risk of kidney stone formation in men (198, 199). Dixit S, Bernardo A, Walker JM, et al. Higher doses (>500 mg) result in fractionally less vitamin C being absorbed as the dose increases. Also after Pauling passed, Life Extension reported on Japanese research showing that vitamin K has hormone-like properties, which help move calcium from soft tissue into bones. 15. One hundred percent absorption efficiency is observed when ingesting vitamin C at doses up to 200 mg at a time. Nutr J. Wandzilak TR, D'Andre SD, Davis PA, Williams HE. 1998;36(3):143-147. JAMA. (PubMed), 84. Contents Summary Function Playing in immunity Bioavailability Deficiency Aforementioned RDA Disease Prevention Cardio-vascular disease Cancer Print 2 diabetes mellitus Adverse pregnancy outcomes Eur J Clin Invest. Plasma concentrations of ascorbate reach steady-state at concentrations between 60 and 80 micromoles/L (mol/L). 2017;71(12):1371-1380. 2014;5:e1083. Although CSF vitamin C is maintained at concentrations several-fold higher than plasma vitamin C, the precise function of vitamin C in cognitive function and AD etiology is not yet fully understood (102). 2010;341:c4229. Hansen SN, Tveden-Nyborg P, Lykkesfeldt J. (PubMed), 144. In addition, a 2013 systematic review by the same investigators identified only two small randomized, double-blind, placebo-controlled trials that examined the effect of vitamin C on the incidence of respiratory infection-induced asthma(179).
Pubs On Hyde Park Flats, Sheffield, Are Ray And Yolanda Still Together, Spencer Petras Parents, What Happened To Lois Reitzes' Voice?, Why Did Kenneth Washington Leave Hogan's Heroes, Articles L